Genetic and cellular evidence of vascular inflammation in neurofibromin-deficient mice and humans

Neurofibromatosis type 1 (NF1) results from mutations in the NF1 tumor suppressor gene, which encodes the protein neurofibromin. NF1 patients display diverse clinical manifestations, including vascular disease, which results from neointima formation and vessel occlusion. However, the pathogenesis of...

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Detalhes bibliográficos
Main Authors: Lasater, Elisabeth A., Li, Fang, Bessler, Waylan K., Estes, Myka L., Vemula, Sasidhar, Hingtgen, Cynthia M., Dinauer, Mary C., Kapur, Reuben, Conway, Simon J., Ingram, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2827964/
https://ncbi.nlm.nih.gov/pubmed/20160346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI41443
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