Neurofibromin Deficiency Induces Endothelial Cell Proliferation and Retinal Neovascularization

PURPOSE: Neurofibromatosis type 1 (NF1) is the result of inherited mutations in the NF1 tumor suppressor gene, which encodes the protein neurofibromin. Eye manifestations are common in NF1 with recent reports describing a vascular dysplasia in the retina and choroid. Common features of NF1 retinopat...

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Pubblicato in:Invest Ophthalmol Vis Sci
Autori principali: Zhang, Hanfang, Hudson, Farlyn Z., Xu, Zhimin, Tritz, Rebekah, Rojas, Modesto, Patel, Chintan, Haigh, Stephen B., Bordán, Zsuzsanna, Ingram, David A., Fulton, David J., Weintraub, Neal L., Caldwell, Ruth B., Stansfield, Brian K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Association for Research in Vision and Ophthalmology 2018
Soggetti:
Retina
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5963003/
https://ncbi.nlm.nih.gov/pubmed/29847659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.17-22588
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