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Loss of GTPase activating protein neurofibromin stimulates paracrine cell communication via macropinocytosis
Neurofibromin, the protein product of the neurofibromatosis type 1 (NF1) tumor suppressor gene, is a negative regulator of Ras signaling. Patients with mutations in NF1 have a strong predisposition for cardiovascular disease, which contributes to their early mortality. Nf1 heterozygous (Nf1(+/−)) bo...
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| 出版年: | Redox Biol |
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| 主要な著者: | , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Elsevier
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6859534/ https://ncbi.nlm.nih.gov/pubmed/31201114 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2019.101224 |
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