Loss of GTPase activating protein neurofibromin stimulates paracrine cell communication via macropinocytosis

Neurofibromin, the protein product of the neurofibromatosis type 1 (NF1) tumor suppressor gene, is a negative regulator of Ras signaling. Patients with mutations in NF1 have a strong predisposition for cardiovascular disease, which contributes to their early mortality. Nf1 heterozygous (Nf1(+/−)) bo...

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Bibliographische Detailangaben
Veröffentlicht in:Redox Biol
Hauptverfasser: Ghoshal, Pushpankur, Singla, Bhupesh, Lin, Huiping, Cherian-Shaw, Mary, Tritz, Rebekah, Padgett, Caleb A., Hudson, Farlyn, Zhang, Hanfang, Stansfield, Brian K., Csányi, Gábor
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2019
Schlagworte:
Inflammation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6859534/
https://ncbi.nlm.nih.gov/pubmed/31201114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2019.101224
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