Acetaminophen inhibits hemoprotein-catalyzed lipid peroxidation and attenuates rhabdomyolysis-induced renal failure

Hemoproteins, hemoglobin and myoglobin, once released from cells can cause severe oxidative damage as a consequence of heme redox cycling between ferric and ferryl states that generates radical species that induce lipid peroxidation. We demonstrate in vitro that acetaminophen inhibits hemoprotein-in...

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Autors principals: Boutaud, Olivier, Moore, Kevin P., Reeder, Brandon J., Harry, David, Howie, Alexander J., Wang, Shuhe, Carney, Clare K., Masterson, Tina S., Amin, Taneem, Wright, David W., Wilson, Michael T., Oates, John A., Roberts, L. Jackson
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2010
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823910/
https://ncbi.nlm.nih.gov/pubmed/20133658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0910174107
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