Acetaminophen inhibits hemoprotein-catalyzed lipid peroxidation and attenuates rhabdomyolysis-induced renal failure

Hemoproteins, hemoglobin and myoglobin, once released from cells can cause severe oxidative damage as a consequence of heme redox cycling between ferric and ferryl states that generates radical species that induce lipid peroxidation. We demonstrate in vitro that acetaminophen inhibits hemoprotein-in...

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Hlavní autoři: Boutaud, Olivier, Moore, Kevin P., Reeder, Brandon J., Harry, David, Howie, Alexander J., Wang, Shuhe, Carney, Clare K., Masterson, Tina S., Amin, Taneem, Wright, David W., Wilson, Michael T., Oates, John A., Roberts, L. Jackson
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2010
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823910/
https://ncbi.nlm.nih.gov/pubmed/20133658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0910174107
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