Acetaminophen inhibits hemoprotein-catalyzed lipid peroxidation and attenuates rhabdomyolysis-induced renal failure

Hemoproteins, hemoglobin and myoglobin, once released from cells can cause severe oxidative damage as a consequence of heme redox cycling between ferric and ferryl states that generates radical species that induce lipid peroxidation. We demonstrate in vitro that acetaminophen inhibits hemoprotein-in...

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Detalhes bibliográficos
Main Authors: Boutaud, Olivier, Moore, Kevin P., Reeder, Brandon J., Harry, David, Howie, Alexander J., Wang, Shuhe, Carney, Clare K., Masterson, Tina S., Amin, Taneem, Wright, David W., Wilson, Michael T., Oates, John A., Roberts, L. Jackson
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823910/
https://ncbi.nlm.nih.gov/pubmed/20133658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0910174107
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