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Engineering Chemoselectivity in Hemoprotein-Catalyzed Indole Amidation
Here we report a cytochrome P450 variant that catalyzes C(2)-amidation of 1-methylindoles with tosyl azide via nitrene transfer. Before evolutionary optimization the enzyme exhibited two undesired side reactivities resulting in reduction of the putative iron-nitrenoid intermediate or cycloaddition b...
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| Publicado no: | ACS Catal |
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| Principais autores: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6959474/ https://ncbi.nlm.nih.gov/pubmed/31938573 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscatal.9b02508 |
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