Carregant...
Engineering Chemoselectivity in Hemoprotein-Catalyzed Indole Amidation
Here we report a cytochrome P450 variant that catalyzes C(2)-amidation of 1-methylindoles with tosyl azide via nitrene transfer. Before evolutionary optimization the enzyme exhibited two undesired side reactivities resulting in reduction of the putative iron-nitrenoid intermediate or cycloaddition b...
Guardat en:
| Publicat a: | ACS Catal |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2019
|
| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6959474/ https://ncbi.nlm.nih.gov/pubmed/31938573 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscatal.9b02508 |
| Etiquetes: |
Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!
|