Non-natural olefin cyclopropanation catalyzed by diverse cytochrome P450s and other hemoproteins

Recent work has shown that engineered variants of cytochrome P450(BM3) (CYP102A1) efficiently catalyze non-natural reactions, including carbene- and nitrene-transfer reactions. Given the broad substrate range of natural P450 enzymes, we set out to explore if this diversity could be leveraged to gene...

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Detaylı Bibliyografya
Yayımlandı:Chembiochem
Asıl Yazarlar: Heel, Thomas, McIntosh, John A., Dodani, Sheel C., Meyerowitz, Joseph T., Arnold, Frances H.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4287214/
https://ncbi.nlm.nih.gov/pubmed/25294253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201402286
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