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USP10 Regulates p53 Localization and Stability by Deubiquitinating p53
p53 stability and localization is essential for its tumor suppressor function. Ubiquitination by the E3 ubiquitin ligase Mdm2 is the major regulatory mechanism of p53, which induces p53 nuclear export and degradation. However, it is unclear whether ubiquitinated cytoplasmic p53 can be recycled. Here...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2820153/ https://ncbi.nlm.nih.gov/pubmed/20096447 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.12.032 |
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