Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13

Autophagy is an important intracellular catabolic mechanism that mediates the degradation of cytoplasmic proteins and organelles. We report a potent small molecule inhibitor of autophagy named “spautin-1” for specific and potent autophagy inhibitor-1. Spautin-1 promotes the degradation of Vps34 PI3...

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Autori principali: Liu, Junli, Xia, Hongguang, Kim, Minsu, Xu, Lihua, Li, Ying, Zhang, Lihong, Cai, Yu, Norberg, Helin Vakifahmetoglu, Zhang, Tao, Furuya, Tsuyoshi, Jin, Minzhi, Zhu, Zhimin, Wang, Huanchen, Yu, Jia, Li, Yanxia, Hao, Yan, Choi, Augustine, Ke, Hengming, Ma, Dawei, Yuan, Junying
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3441147/
https://ncbi.nlm.nih.gov/pubmed/21962518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.08.037
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