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Regulation of p53 stability and function by the deubiquitinating enzyme USP42
The p53 tumour suppressor protein is a transcription factor that prevents oncogenic progression by activating the expression of apoptosis and cell-cycle arrest genes in stressed cells. The stability of p53 is tightly regulated by ubiquitin-dependent degradation, driven mainly by the ubiquitin ligase...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Publishing Group
2011
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3243628/ https://ncbi.nlm.nih.gov/pubmed/22085928 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.419 |
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