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Regulation of p53 stability and function by the deubiquitinating enzyme USP42

The p53 tumour suppressor protein is a transcription factor that prevents oncogenic progression by activating the expression of apoptosis and cell-cycle arrest genes in stressed cells. The stability of p53 is tightly regulated by ubiquitin-dependent degradation, driven mainly by the ubiquitin ligase...

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Bibliografische gegevens
Hoofdauteurs: Hock, Andreas K, Vigneron, Arnaud M, Carter, Stephanie, Ludwig, Robert L, Vousden, Karen H
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2011
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3243628/
https://ncbi.nlm.nih.gov/pubmed/22085928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.419
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