Ubiquitin-specific Peptidase 42 (USP42) Functions to Deubiquitylate Histones and Regulate Transcriptional Activity

Ubiquitin-specific peptidase 42 (USP42) is a deubiquitylating enzyme that can target p53 and contribute to the stabilization of p53 in response to stress. We now show that USP42 can also regulate transcription independently of p53. USP42 co-localized with RNA polymerase II (RNA Pol II) in nuclear fo...

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Udgivet i:J Biol Chem
Main Authors: Hock, Andreas K., Vigneron, Arnaud M., Vousden, Karen H.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Gene Regulation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4263885/
https://ncbi.nlm.nih.gov/pubmed/25336640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.589267
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