OTUD5 Regulates p53 Stability by Deubiquitinating p53

BACKGROUND: The p53 tumour suppressor protein is a transcription factor that prevents oncogenic progression by activating the expression of apoptosis and cell-cycle arrest genes in stressed cells. The stability of p53 is tightly regulated by ubiquitin-dependent degradation, driven mainly by its nega...

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Bibliographic Details
Main Authors: Luo, Judong, Lu, Zhonghua, Lu, Xujing, Chen, Ling, Cao, Jianping, Zhang, Shuyu, Ling, Yang, Zhou, Xifa
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3797110/
https://ncbi.nlm.nih.gov/pubmed/24143256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0077682
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