OTUD5 promotes innate antiviral and antitumor immunity through deubiquitinating and stabilizing STING

Stimulator of interferon genes (STING) is an adaptor protein that is critical for effective innate antiviral and antitumor immunity. The activity of STING is heavily regulated by protein ubiquitination, which is fine-tuned by both E3 ubiquitin ligases and deubiquitinases. Here, we report that the de...

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Detalhes bibliográficos
Publicado no:Cell Mol Immunol
Main Authors: Guo, Yunyun, Jiang, Fei, Kong, Lingli, Wu, Haifeng, Zhang, Honghai, Chen, Xiaorong, Zhao, Jian, Cai, Baoshan, Li, Yanqi, Ma, Chunhong, Yi, Fan, Zhang, Lei, Liu, Bingyu, Zheng, Yi, Zhang, Lingqiang, Gao, Chengjiang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8322343/
https://ncbi.nlm.nih.gov/pubmed/32879469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41423-020-00531-5
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