USP18 recruits USP20 to promote innate antiviral response through deubiquitinating STING/MITA

STING (also known as MITA) mediates the innate antiviral signaling and ubiquitination of STING is key to its function. However, the deubiquitination process of STING is unclear. Here we report that USP18 recruits USP20 to deconjugate K48-linked ubiquitination chains from STING and promotes the stabi...

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Enregistré dans:
Détails bibliographiques
Publié dans:Cell Res
Auteurs principaux: Zhang, Man, Zhang, Meng-Xin, Zhang, Qiang, Zhu, Gao-Feng, Yuan, Lei, Zhang, Dong-Er, Zhu, Qiyun, Yao, Jing, Shu, Hong-Bing, Zhong, Bo
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2016
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5143414/
https://ncbi.nlm.nih.gov/pubmed/27801882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2016.125
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