USP18 recruits USP20 to promote innate antiviral response through deubiquitinating STING/MITA

STING (also known as MITA) mediates the innate antiviral signaling and ubiquitination of STING is key to its function. However, the deubiquitination process of STING is unclear. Here we report that USP18 recruits USP20 to deconjugate K48-linked ubiquitination chains from STING and promotes the stabi...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell Res
Egile Nagusiak: Zhang, Man, Zhang, Meng-Xin, Zhang, Qiang, Zhu, Gao-Feng, Yuan, Lei, Zhang, Dong-Er, Zhu, Qiyun, Yao, Jing, Shu, Hong-Bing, Zhong, Bo
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2016
Gaiak:
Original Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5143414/
https://ncbi.nlm.nih.gov/pubmed/27801882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2016.125
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