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USP49 negatively regulates cellular antiviral responses via deconjugating K63-linked ubiquitination of MITA
Mediator of IRF3 activation (MITA, also known as STING and ERIS) is an essential adaptor protein for cytoplasmic DNA-triggered signaling and involved in innate immune responses, autoimmunity and tumorigenesis. The activity of MITA is critically regulated by ubiquitination and deubiquitination. Here,...
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| Publicado no: | PLoS Pathog |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6464240/ https://ncbi.nlm.nih.gov/pubmed/30943264 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007680 |
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