USP49 negatively regulates cellular antiviral responses via deconjugating K63-linked ubiquitination of MITA

Mediator of IRF3 activation (MITA, also known as STING and ERIS) is an essential adaptor protein for cytoplasmic DNA-triggered signaling and involved in innate immune responses, autoimmunity and tumorigenesis. The activity of MITA is critically regulated by ubiquitination and deubiquitination. Here,...

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Dettagli Bibliografici
Pubblicato in:PLoS Pathog
Autori principali: Ye, Liya, Zhang, Qiang, Liuyu, Tianzi, Xu, Zhigao, Zhang, Meng-Xin, Luo, Min-Hua, Zeng, Wen-Bo, Zhu, Qiyun, Lin, Dandan, Zhong, Bo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6464240/
https://ncbi.nlm.nih.gov/pubmed/30943264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007680
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