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USP29 maintains the stability of cGAS and promotes cellular antiviral responses and autoimmunity

Cyclic GMP-AMP synthase (cGAS) is an essential sensor of cytosolic DNA and critically mediates innate immune responses and autoimmunity. Modulating the activity and stability of cGAS provides potential strategies for treating viral or autoimmune diseases. Here, we report that ubiquitin-specific prot...

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Detalhes bibliográficos
Publicado no:Cell Res
Main Authors: Zhang, Qiang, Tang, Zhen, An, Ran, Ye, Liya, Zhong, Bo
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Singapore 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7608407/
https://ncbi.nlm.nih.gov/pubmed/32457395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41422-020-0341-6
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