USP44 positively regulates innate immune response to DNA viruses through deubiquitinating MITA

Mediator of IRF3 activation (MITA, also known as stimulator of interferon genes, STING) senses the second messenger cyclic GMP-AMP (cGAMP) which is synthesized upon DNA virus infection and activates innate antiviral immune response. It has been demonstrated that the activity of MITA is delicately re...

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Bibliographic Details
Published in:PLoS Pathog
Main Authors: Zhang, Hong-Yan, Liao, Bo-Wei, Xu, Zhi-Sheng, Ran, Yong, Wang, Dong-Peng, Yang, Yan, Luo, Wei-Wei, Wang, Yan-Yi
Format: Artigo
Language:Inglês
Published: Public Library of Science 2020
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6975528/
https://ncbi.nlm.nih.gov/pubmed/31968013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008178
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