USP13 negatively regulates antiviral responses by deubiquitinating STING

STING (also known as MITA) is critical for host defence against viruses and the activity of STING is regulated by ubiquitination. However, the deubiquitination of STING is not fully understood. Here, we show that ubiquitin-specific protease 13 (USP13) is a STING-interacting protein that catalyses de...

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Vydáno v:Nat Commun
Hlavní autoři: Sun, He, Zhang, Qiang, Jing, Ying-Ying, Zhang, Man, Wang, Hai-Ying, Cai, Zeng, Liuyu, Tianzi, Zhang, Zhi-Dong, Xiong, Tian-Chen, Wu, Yan, Zhu, Qi-Yun, Yao, Jing, Shu, Hong-Bing, Lin, Dandan, Zhong, Bo
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5457515/
https://ncbi.nlm.nih.gov/pubmed/28534493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15534
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