OTUD5 promotes innate antiviral and antitumor immunity through deubiquitinating and stabilizing STING

Stimulator of interferon genes (STING) is an adaptor protein that is critical for effective innate antiviral and antitumor immunity. The activity of STING is heavily regulated by protein ubiquitination, which is fine-tuned by both E3 ubiquitin ligases and deubiquitinases. Here, we report that the de...

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Veröffentlicht in:Cell Mol Immunol
Hauptverfasser: Guo, Yunyun, Jiang, Fei, Kong, Lingli, Wu, Haifeng, Zhang, Honghai, Chen, Xiaorong, Zhao, Jian, Cai, Baoshan, Li, Yanqi, Ma, Chunhong, Yi, Fan, Zhang, Lei, Liu, Bingyu, Zheng, Yi, Zhang, Lingqiang, Gao, Chengjiang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8322343/
https://ncbi.nlm.nih.gov/pubmed/32879469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41423-020-00531-5
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