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USP18 positively regulates innate antiviral immunity by promoting K63-linked polyubiquitination of MAVS
Activation of MAVS, an adaptor molecule in Rig-I-like receptor (RLR) signaling, is indispensable for antiviral immunity, yet the molecular mechanisms modulating MAVS activation are not completely understood. Ubiquitination has a central function in regulating the activity of MAVS. Here, we demonstra...
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| Publié dans: | Nat Commun |
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| Auteurs principaux: | , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group UK
2021
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8137702/ https://ncbi.nlm.nih.gov/pubmed/34016972 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23219-4 |
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