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Resistance to IFN-alpha-induced apoptosis is linked to a loss of STAT2

Type I interferons (IFN-α/β) are pleitropic cytokines widely used in the treatment of certain malignancies, hepatitis B and C and multiple sclerosis. IFN resistance is a challenging clinical problem to overcome. Hence understanding the molecular mechanism by which IFN immunotherapy ceases to be effe...

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Autors principals: Romero-Weaver, Ana L., Wang, Hsiang-Wen, Steen, Håkan C., Scarzello, Anthony J., Hall, Veronica L., Sheikh, Faruk, Donnelly, Raymond P., Gamero, Ana M.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2808460/
https://ncbi.nlm.nih.gov/pubmed/20068068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-08-0344
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