A Mutation in the SH2 Domain of STAT2 Prolongs Tyrosine Phosphorylation of STAT1 and Promotes Type I IFN-induced Apoptosis

Type I interferons (IFN-α/β) induce apoptosis in certain tumor cell lines but not others. Here we describe a mutation in STAT2 that confers an apoptotic effect in tumor cells in response to type I IFNs. This mutation was introduced in a conserved motif, PYTK, located in the STAT SH2 domain, which is...

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Autori principali: Scarzello, Anthony J., Romero-Weaver, Ana L., Maher, Stephen G., Veenstra, Timothy D., Zhou, Ming, Qin, Angel, Donnelly, Raymond P., Sheikh, Faruk, Gamero, Ana M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Cell Biology 2007
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1924825/
https://ncbi.nlm.nih.gov/pubmed/17442890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E06-09-0843
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