IFN-α and IFN-λ differ in their antiproliferative effects and duration of JAK/STAT signaling activity

Interferon (IFN)-λ, also known as IL-28A, IL-28B or IL-29, is a new type III IFN, which like type I IFN-(α/β), activates common elements of the JAK/STAT signaling pathway and exhibits antiproliferative activity. Currently, IFN-α is used in the treatment of certain forms of cancer, but its antitumor...

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Bibliographic Details
Main Authors: Maher, Stephen G., Sheikh, Faruk, Scarzello, Anthony J., Romero-Weaver, Ana L., Baker, Darren P., Donnelly, Raymond P., Gamero, Ana M.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2435218/
https://ncbi.nlm.nih.gov/pubmed/18698163
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