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An essential role for IFN-β in the induction of IFN-stimulated gene expression by LPS in macrophages

TLR agonists such as LPS and poly(I:C) induce expression of type I IFNs, such as IFN-α and -β, by macrophages. To examine the role of IFN-β in the induction of ISGs by LPS, we compared the ability of LPS to induce ISGF3 activity and ISG expression in bone marrow–derived macrophages from WT and Ifnb1...

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Bibliographic Details
Main Authors: Sheikh, Faruk, Dickensheets, Harold, Gamero, Ana M., Vogel, Stefanie N., Donnelly, Raymond P.
Format: Artigo
Language:Inglês
Published: Society for Leukocyte Biology 2014
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4163629/
https://ncbi.nlm.nih.gov/pubmed/25024400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.2A0414-191R
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