The Interleukin-13 Receptor-α1 Chain Is Essential for Induction of the Alternative Macrophage Activation Pathway by IL-13 but Not IL-4

Macrophages coexpress both the interleukin (IL)-2Rγ chain (γ(c)) and IL-13Rα1. These receptor chains can heterodimerize with IL-4Rα to form type I or type II IL-4 receptor complexes, respectively. We used macrophages derived from Il2rg and Il13ra1 knockout (KO) mice to evaluate the requirements for...

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Detalhes bibliográficos
Publicado no:J Innate Immun
Main Authors: Sheikh, Faruk, Dickensheets, Harold, Pedras-Vasconcelos, Joao, Ramalingam, Thirumalai, Helming, Laura, Gordon, Siamon, Donnelly, Raymond P.
Formato: Artigo
Idioma:Inglês
Publicado em: S. Karger AG 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4553078/
https://ncbi.nlm.nih.gov/pubmed/25766112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000376579
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