Tuning sensitivity to IL-4 and IL-13: differential expression of IL-4Rα, IL-13Rα1, and γc regulates relative cytokine sensitivity

Interleukin (IL)-4 and -13 are related cytokines sharing functional receptors. IL-4 signals through the type I (IL-4Rα/common γ-chain [γc]) and the type II (IL-4Rα/-13Rα1) IL-4 receptors, whereas IL-13 utilizes only the type II receptor. In this study, we show that mouse bone marrow–derived macropha...

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Bibliographic Details
Main Authors: Junttila, Ilkka S., Mizukami, Kiyoshi, Dickensheets, Harold, Meier-Schellersheim, Martin, Yamane, Hidehiro, Donnelly, Raymond P., Paul, William E.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2008
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2571934/
https://ncbi.nlm.nih.gov/pubmed/18852293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20080452
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