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STAT2 phosphorylation and signaling

STAT2 is an essential transcription factor in type I IFN mediated anti-viral and anti-proliferative signaling. STAT2 function is regulated by tyrosine phosphorylation, which is the trigger for STAT-dimerization, subsequent nuclear translocation, and transcriptional activation of IFN stimulated genes...

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Main Authors: Steen, Håkan C, Gamero, Ana M
Formato: Artigo
Idioma:Inglês
Publicado: Landes Bioscience 2013
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3876438/
https://ncbi.nlm.nih.gov/pubmed/24416652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/jkst.25790
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