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Evaluation of Di-Sansalvamide A derivatives: Synthesis, structure-activity relationship, and mechanism of action
Described is the SAR of 18 Di-Sansalvamide A derivatives and the mechanism of action of the most potent compound. We show that this scaffold is a promising lead in the development of novel cancer therapeutics because it is: cytotoxic at nanomolar potency, inhibits a well-established oncogenic target...
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| Autores principales: | , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2805559/ https://ncbi.nlm.nih.gov/pubmed/20014866 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm901566c |
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