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PCR-free method detects high frequency of genomic instability in prostate cancer
Most studies of tumor instability are PCR-based. PCR-based methods may underestimate mutation frequencies of heterogeneous tumor genomes. Using a novel PCR-free random cloning/sequencing method, we analyzed 100 kb of total genomic DNA from blood lymphocytes, normal prostate and tumor prostate taken...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2794161/ https://ncbi.nlm.nih.gov/pubmed/19797393 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp761 |
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