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PCR-free method detects high frequency of genomic instability in prostate cancer

Most studies of tumor instability are PCR-based. PCR-based methods may underestimate mutation frequencies of heterogeneous tumor genomes. Using a novel PCR-free random cloning/sequencing method, we analyzed 100 kb of total genomic DNA from blood lymphocytes, normal prostate and tumor prostate taken...

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Detalhes bibliográficos
Main Authors: Makridakis, Nick M., Phipps, Troy, Srivastav, Sudesh, Reichardt, Juergen K. V.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2794161/
https://ncbi.nlm.nih.gov/pubmed/19797393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp761
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