Potential for genomic instability associated with retrotranspositionally-incompetent L1 loci

Expression of the L1 retrotransposon can damage the genome through insertional mutagenesis and the generation of DNA double-strand breaks (DSBs). The majority of L1 loci in the human genome are 5′-truncated and therefore incapable of retrotransposition. While thousands of full-length L1 loci remain,...

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Hlavní autoři: Kines, Kristine J., Sokolowski, Mark, deHaro, Dawn L., Christian, Claiborne M., Belancio, Victoria P.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2014
Témata:
Genome Integrity, Repair and Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176336/
https://ncbi.nlm.nih.gov/pubmed/25143528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku687
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