Učitavanje...
Potential for genomic instability associated with retrotranspositionally-incompetent L1 loci
Expression of the L1 retrotransposon can damage the genome through insertional mutagenesis and the generation of DNA double-strand breaks (DSBs). The majority of L1 loci in the human genome are 5′-truncated and therefore incapable of retrotransposition. While thousands of full-length L1 loci remain,...
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| Glavni autori: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Oxford University Press
2014
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4176336/ https://ncbi.nlm.nih.gov/pubmed/25143528 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku687 |
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