Prostate cancer-associated SPOP mutations lead to genomic instability through disruption of the SPOP–HIPK2 axis

Speckle-type Poz protein (SPOP), an E3 ubiquitin ligase adaptor, is the most frequently mutated gene in prostate cancer. The SPOP-mutated subtype of prostate cancer shows high genomic instability, but the underlying mechanisms causing this phenotype are still largely unknown. Here, we report that up...

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Publicado en:Nucleic Acids Res
Autores principales: Jin, Xiaofeng, Qing, Shi, Li, Qian, Zhuang, Hui, Shen, Liliang, Li, Jinhui, Qi, Honggang, Lin, Ting, Lin, Zihan, Wang, Jian, Cao, Xinyi, Yang, Jianye, Ma, Qi, Cong, Linghua, Xi, Yang, Fang, Shuai, Meng, Xiaodan, Gong, Zhaohui, Ye, Meng, Wang, Shuyun, Wang, Chenji, Gao, Kun
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2021
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8266658/
https://ncbi.nlm.nih.gov/pubmed/34133717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab489
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