SPOP promotes transcriptional expression of DNA repair and replication factors to prevent replication stress and genomic instability

Mutations in SPOP, the gene most frequently point-mutated in primary prostate cancer, are associated with a high degree of genomic instability and deficiency in homologous recombination repair of DNA but the underlying mechanisms behind this defect are currently unknown. Here we demonstrate that SPO...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Hjorth-Jensen, Kim, Maya-Mendoza, Apolinar, Dalgaard, Nanna, Sigurðsson, Jón O, Bartek, Jiri, Iglesias-Gato, Diego, Olsen, Jesper V, Flores-Morales, Amilcar
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6182143/
https://ncbi.nlm.nih.gov/pubmed/30124983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky719
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados