SPOP promotes transcriptional expression of DNA repair and replication factors to prevent replication stress and genomic instability

Mutations in SPOP, the gene most frequently point-mutated in primary prostate cancer, are associated with a high degree of genomic instability and deficiency in homologous recombination repair of DNA but the underlying mechanisms behind this defect are currently unknown. Here we demonstrate that SPO...

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Publicat a:Nucleic Acids Res
Autors principals: Hjorth-Jensen, Kim, Maya-Mendoza, Apolinar, Dalgaard, Nanna, Sigurðsson, Jón O, Bartek, Jiri, Iglesias-Gato, Diego, Olsen, Jesper V, Flores-Morales, Amilcar
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2018
Matèries:
Genome Integrity, Repair and Replication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6182143/
https://ncbi.nlm.nih.gov/pubmed/30124983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky719
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