The S218L familial hemiplegic migraine mutation promotes deinhibition of Ca(v)2.1 calcium channels during direct G-protein regulation

Familial hemiplegic migraine type 1 (FHM-1) is caused by mutations in CACNA1A; the gene encoding for the Ca(v)2.1 subunit of voltage-gated calcium channels. Although various studies attempted to determine biophysical consequences of these mutations on channel activity, it remains unclear exactly how...

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Hlavní autoři: Weiss, Norbert, Sandoval, Alejandro, Felix, Ricardo, Van den Maagdenberg, Arn, De Waard, Michel
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2793404/
https://ncbi.nlm.nih.gov/pubmed/18581134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00424-008-0541-2
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