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The S218L familial hemiplegic migraine mutation promotes deinhibition of Ca(v)2.1 calcium channels during direct G-protein regulation
Familial hemiplegic migraine type 1 (FHM-1) is caused by mutations in CACNA1A; the gene encoding for the Ca(v)2.1 subunit of voltage-gated calcium channels. Although various studies attempted to determine biophysical consequences of these mutations on channel activity, it remains unclear exactly how...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Springer
2008
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2793404/ https://ncbi.nlm.nih.gov/pubmed/18581134 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00424-008-0541-2 |
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