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Overexpressed Na(V)1.7 Channels Confer Hyperexcitability to in vitro Trigeminal Sensory Neurons of Ca(V)2.1 Mutant Hemiplegic Migraine Mice
Trigeminal sensory neurons of transgenic knock-in (KI) mice expressing the R192Q missense mutation in the α1A subunit of neuronal voltage-gated Ca(V)2.1 Ca(2+) channels, which leads to familial hemiplegic migraine type 1 (FHM1) in patients, exhibit a hyperexcitability phenotype. Here, we show that t...
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| Publicado no: | Front Cell Neurosci |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8185157/ https://ncbi.nlm.nih.gov/pubmed/34113237 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2021.640709 |
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