Mutation in the Heparan Sulfate Biosynthesis Enzyme EXT1 Influences Growth Factor Signaling and Fibroblast Interactions with the Extracellular Matrix

Heparan sulfate (HS) chains bind and modulate the signaling efficiency of many ligands, including members of the fibroblast growth factor (FGF) and platelet-derived growth factor families. We previously reported the structure of HS synthesized by embryonic fibroblasts from mice with a gene trap muta...

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מידע ביבליוגרפי
Main Authors: Österholm, Cecilia, Barczyk, Malgorzata M., Busse, Marta, Grønning, Mona, Reed, Rolf K., Kusche-Gullberg, Marion
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2009
נושאים:
Glycobiology and Extracellular Matrices
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787356/
https://ncbi.nlm.nih.gov/pubmed/19850926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.005264
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