Mutation in the Heparan Sulfate Biosynthesis Enzyme EXT1 Influences Growth Factor Signaling and Fibroblast Interactions with the Extracellular Matrix

Heparan sulfate (HS) chains bind and modulate the signaling efficiency of many ligands, including members of the fibroblast growth factor (FGF) and platelet-derived growth factor families. We previously reported the structure of HS synthesized by embryonic fibroblasts from mice with a gene trap muta...

Full description

Saved in:
Bibliographic Details
Main Authors: Österholm, Cecilia, Barczyk, Malgorzata M., Busse, Marta, Grønning, Mona, Reed, Rolf K., Kusche-Gullberg, Marion
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Glycobiology and Extracellular Matrices
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787356/
https://ncbi.nlm.nih.gov/pubmed/19850926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.005264
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items