Mutation in the Heparan Sulfate Biosynthesis Enzyme EXT1 Influences Growth Factor Signaling and Fibroblast Interactions with the Extracellular Matrix

Heparan sulfate (HS) chains bind and modulate the signaling efficiency of many ligands, including members of the fibroblast growth factor (FGF) and platelet-derived growth factor families. We previously reported the structure of HS synthesized by embryonic fibroblasts from mice with a gene trap muta...

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Detalles Bibliográficos
Main Authors: Österholm, Cecilia, Barczyk, Malgorzata M., Busse, Marta, Grønning, Mona, Reed, Rolf K., Kusche-Gullberg, Marion
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Glycobiology and Extracellular Matrices
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787356/
https://ncbi.nlm.nih.gov/pubmed/19850926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.005264
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