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Heparan sulfate biosynthesis enzymes EXT1 and EXT2 affect NDST1 expression and heparan sulfate sulfation

Heparan sulfate (HS) proteoglycans influence embryonic development and adult physiology through interactions with protein ligands. The interactions depend on HS structure, which is determined largely during biosynthesis by Golgi enzymes. How biosynthesis is regulated is more or less unknown. During...

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Detalhes bibliográficos
Main Authors: Presto, Jenny, Thuveson, Maria, Carlsson, Pernilla, Busse, Marta, Wilén, Maria, Eriksson, Inger, Kusche-Gullberg, Marion, Kjellén, Lena
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2290785/
https://ncbi.nlm.nih.gov/pubmed/18337501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0705807105
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