Heparan sulfate biosynthesis enzymes EXT1 and EXT2 affect NDST1 expression and heparan sulfate sulfation

Heparan sulfate (HS) proteoglycans influence embryonic development and adult physiology through interactions with protein ligands. The interactions depend on HS structure, which is determined largely during biosynthesis by Golgi enzymes. How biosynthesis is regulated is more or less unknown. During...

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Bibliographic Details
Main Authors: Presto, Jenny, Thuveson, Maria, Carlsson, Pernilla, Busse, Marta, Wilén, Maria, Eriksson, Inger, Kusche-Gullberg, Marion, Kjellén, Lena
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2008
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2290785/
https://ncbi.nlm.nih.gov/pubmed/18337501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0705807105
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