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Heparan sulfate biosynthesis enzymes EXT1 and EXT2 affect NDST1 expression and heparan sulfate sulfation

Heparan sulfate (HS) proteoglycans influence embryonic development and adult physiology through interactions with protein ligands. The interactions depend on HS structure, which is determined largely during biosynthesis by Golgi enzymes. How biosynthesis is regulated is more or less unknown. During...

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Hlavní autoři: Presto, Jenny, Thuveson, Maria, Carlsson, Pernilla, Busse, Marta, Wilén, Maria, Eriksson, Inger, Kusche-Gullberg, Marion, Kjellén, Lena
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2290785/
https://ncbi.nlm.nih.gov/pubmed/18337501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0705807105
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