Mutation in the Heparan Sulfate Biosynthesis Enzyme EXT1 Influences Growth Factor Signaling and Fibroblast Interactions with the Extracellular Matrix

Heparan sulfate (HS) chains bind and modulate the signaling efficiency of many ligands, including members of the fibroblast growth factor (FGF) and platelet-derived growth factor families. We previously reported the structure of HS synthesized by embryonic fibroblasts from mice with a gene trap muta...

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Hlavní autoři: Österholm, Cecilia, Barczyk, Malgorzata M., Busse, Marta, Grønning, Mona, Reed, Rolf K., Kusche-Gullberg, Marion
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2009
Témata:
Glycobiology and Extracellular Matrices
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787356/
https://ncbi.nlm.nih.gov/pubmed/19850926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.005264
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