Design and construction of diverse mammalian prion strains

Prions are infectious proteins that encipher biological information within their conformations; variations in these conformations dictate different prion strains. Toward elucidating the molecular language of prion protein (PrP) conformations, we produced an array of recombinant PrP amyloids with var...

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Bibliographic Details
Main Authors: Colby, David W., Giles, Kurt, Legname, Giuseppe, Wille, Holger, Baskakov, Ilia V., DeArmond, Stephen J., Prusiner, Stanley B.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2009
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787151/
https://ncbi.nlm.nih.gov/pubmed/19915150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0910350106
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