Prions

par Colby, David W., Prusiner, Stanley B.
Publié 2011

De novo generation of prion strains

par Colby, David W., Prusiner, Stanley B.
Publié 2011

Conformation dependent epitopes recognized by prion protein antibodies probed using mutational scanning and deep sequencing

par Doolan, Kyle M., Colby, David W.
Publié dans J Mol Biol (2014)

Protein Misfolding Detected Early in Pathogenesis of Transgenic Mouse Model of Huntington Disease Using Amyloid Seeding Assay

par Gupta, Sharad, Jie, Shy'Ann, Colby, David W.
Publié 2012

Designing well-defined photopolymerized synthetic matrices for three-dimensional culture and differentiation of induced pluripotent stem cells

par Ovadia, Elisa M., Colby, David W., Kloxin, April M.
Publié dans Biomater Sci (2018)

Conformational features of tau fibrils from Alzheimer’s disease brain are faithfully propagated by unmodified recombinant protein

par Morozova, Olga A., March, Zachary M., Robinson, Anne S., Colby, David W.
Publié 2013

Prion detection by an amyloid seeding assay

par Colby, David W., Zhang, Qiang, Wang, Shuyi, Groth, Darlene, Legname, Giuseppe, Riesner, Detlev, Prusiner, Stanley B.
Publié 2007

Design and construction of diverse mammalian prion strains

par Colby, David W., Giles, Kurt, Legname, Giuseppe, Wille, Holger, Baskakov, Ilia V., DeArmond, Stephen J., Prusiner, Stanley B.
Publié 2009

Convergent Replication of Mouse Synthetic Prion Strains

par Ghaemmaghami, Sina, Colby, David W., Nguyen, Hoang-Oanh B., Hayashi, Shigenari, Oehler, Abby, DeArmond, Stephen J., Prusiner, Stanley B.
Publié 2013

Potent inhibition of huntingtin aggregation and cytotoxicity by a disulfide bond-free single-domain intracellular antibody

par Colby, David W., Chu, YiJia, Cassady, John P., Duennwald, Martin, Zazulak, Helen, Webster, Jack M., Messer, Anne, Lindquist, Susan, Ingram, Vernon Martin, Wittrup, K. Dane
Publié 2004

Small-molecule aggregates inhibit amyloid polymerization

par Feng, Brian Y, Toyama, Brandon H, Wille, Holger, Colby, David W, Collins, Sean R, May, Barnaby C H, Prusiner, Stanley B, Weissman, Jonathan, Shoichet, Brian K
Publié 2008

The N-terminus of the prion protein is a toxic effector regulated by the C-terminus

par Wu, Bei, McDonald, Alex J, Markham, Kathleen, Rich, Celeste B, McHugh, Kyle P, Tatzelt, Jörg, Colby, David W, Millhauser, Glenn L, Harris, David A
Publié dans eLife (2017)

Natural and synthetic prion structure from X-ray fiber diffraction

par Wille, Holger, Bian, Wen, McDonald, Michele, Kendall, Amy, Colby, David W., Bloch, Lillian, Ollesch, Julian, Borovinskiy, Alexander L., Cohen, Fred E., Prusiner, Stanley B., Stubbs, Gerald
Publié 2009

Protease-Sensitive Synthetic Prions

par Colby, David W., Wain, Rachel, Baskakov, Ilia V., Legname, Giuseppe, Palmer, Christina G., Nguyen, Hoang-Oanh B., Lemus, Azucena, Cohen, Fred E., DeArmond, Stephen J., Prusiner, Stanley B.
Publié 2010

Inert and seed-competent tau monomers suggest structural origins of aggregation

par Mirbaha, Hilda, Chen, Dailu, Morazova, Olga A, Ruff, Kiersten M, Sharma, Apurwa M, Liu, Xiaohua, Goodarzi, Mohammad, Pappu, Rohit V, Colby, David W, Mirzaei, Hamid, Joachimiak, Lukasz A, Diamond, Marc I
Publié dans eLife (2018)

Comparative study of naturally occurring huntingtin fragments in Drosophila points to exon 1 as the most pathogenic species in Huntington's disease

par Barbaro, Brett A., Lukacsovich, Tamas, Agrawal, Namita, Burke, John, Bornemann, Doug J., Purcell, Judith M., Worthge, Shane A., Caricasole, Andrea, Weiss, Andreas, Song, Wan, Morozova, Olga A., Colby, David W., Marsh, J. Lawrence
Publié dans Hum Mol Genet (2015)