Small-molecule aggregates inhibit amyloid polymerization

Many amyloid inhibitors resemble molecules that form chemical aggregates, which are known to inhibit many proteins. Eight known chemical aggregators inhibited amyloid formation of the yeast and mouse prion proteins Sup35 and recMoPrP in a manner characteristic of colloidal inhibition. Similarly, thr...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Feng, Brian Y, Toyama, Brandon H, Wille, Holger, Colby, David W, Collins, Sean R, May, Barnaby C H, Prusiner, Stanley B, Weissman, Jonathan, Shoichet, Brian K
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2008
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2730835/
https://ncbi.nlm.nih.gov/pubmed/18223646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.65
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