Small-molecule aggregates inhibit amyloid polymerization

Many amyloid inhibitors resemble molecules that form chemical aggregates, which are known to inhibit many proteins. Eight known chemical aggregators inhibited amyloid formation of the yeast and mouse prion proteins Sup35 and recMoPrP in a manner characteristic of colloidal inhibition. Similarly, thr...

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Detalhes bibliográficos
Main Authors: Feng, Brian Y, Toyama, Brandon H, Wille, Holger, Colby, David W, Collins, Sean R, May, Barnaby C H, Prusiner, Stanley B, Weissman, Jonathan, Shoichet, Brian K
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2730835/
https://ncbi.nlm.nih.gov/pubmed/18223646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.65
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