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Small-molecule aggregates inhibit amyloid polymerization
Many amyloid inhibitors resemble molecules that form chemical aggregates, which are known to inhibit many proteins. Eight known chemical aggregators inhibited amyloid formation of the yeast and mouse prion proteins Sup35 and recMoPrP in a manner characteristic of colloidal inhibition. Similarly, thr...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2730835/ https://ncbi.nlm.nih.gov/pubmed/18223646 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.65 |
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